Synergistic Protection of L-Arginine and Vitamin E On Lipid Peroxidation of Asthenospermic Patients
نویسنده
چکیده
Background: Lipid peroxidation is known to cause various impairments to sperm cells and may play a major role in the etiology of male infertility. Asthenospermia is the main factor of male infertility and has significantly higher level of peroxidation than in normozoospermic males. Materials and Methods: Using thiobarbituric acid (TBA) assay procedure, we have determined the level of lipid peroxidation as indicated by malondialdehyde (MDA) in the spermatozoa obtained from asthenospermic male semen. Results: An inverse correlation of MDA concentration with sperm motility is observed. Treatment of cells with L-arginine and vitamin E significantly decreases the MDA concentration and improves the sperm motility as compared to that in case of control samples. A combination of L-arginine and vitamin E shows synergistic effect on sperm motility and prevention of lipid peroxidation. Conclusion: L-arginine and vitamin E protect the cells against the loss of sperm motility by lipid peroxidation. Therefore, supplementation of both L-arginine and vitamin E may improve sperm motility and increase the possibility of fertilization in asthenospermic subjects.
منابع مشابه
Synergistic Protection of L-Arginine and Vitamin E On Lipid Peroxidation of Asthenospermic Patients
Background Lipid peroxidation is known to cause various impairments to sperm cells and may play a major role in the etiology of male infertility. Asthenospermia is the main factor of male infertility and has significantly higher level of peroxidation than in normozoospermic males. MaterialsAndMethods Using thiobarbituric acid (TBA) assay procedure, we have determined the level of lipid peroxida...
متن کاملRestorative Effect of Vitamin E Supplementation on Hepatic Lipid Peroxidation and Lipid Profile Changes Induced by Sublethal γ-Radiation in BALB/c Mice
In order to find a prophylactic supplementation for individuals who are at risk of exposure to ionizing radiation, we attempted to evaluate the effect of Vitamin E (Vit-E), a biological free radical scavenger, on restoration of hepatic lipid peroxidation (LPO) and lipid profile (LP) changes induced by sublethal g- radiation in BALB/c mice. The concentrations of cholesterol and phospholipid were...
متن کاملThe Antioxidant Vitamin (A, C, E) and the Lipid Peroxidation Levels in Some Tissues of Juvenile Rainbow trout (Oncorhynchus mykiss, W. 1792) at Different Oxygen Levels
In this study, the malondialdehyde (MDA) levels in the muscle, liver and kidney tissues and the antioxidant vitamin (A, C, E) levels in the muscle tissue of juvenile rainbow trout were investigated under different oxygen levels (3.5 mg O2/l, 4.5 mg O2/l and 7 mg O2/l) at the end of the 8 hour trial. Fish (initial weight and length, 30.19±2.2 g and 13.15±0.22 cm, respectively) were distributed i...
متن کاملThe Antioxidant Vitamin (A, C, E) and the Lipid Peroxidation Levels in Some Tissues of Juvenile Rainbow trout (Oncorhynchus mykiss, W. 1792) at Different Oxygen Levels
In this study, the malondialdehyde (MDA) levels in the muscle, liver and kidney tissues and the antioxidant vitamin (A, C, E) levels in the muscle tissue of juvenile rainbow trout were investigated under different oxygen levels (3.5 mg O2/l, 4.5 mg O2/l and 7 mg O2/l) at the end of the 8 hour trial. Fish (initial weight and length, 30.19±2.2 g and 13.15±0.22 cm, respectively) were dis...
متن کاملAntioxidant Enzymes and Oxidative Stress in the Erythrocytes of Iron Deficiency Anemic Patients Supplemented with Vitamins
Background: Iron deficiency anemia is one of the major causes of morbidity and mortality worldwide. Evidences from epidemiological and clinical studies suggest a possible correlation between antioxidant levels and the anemic disease risk. The present work is to investigate antioxidant levels and lipid peroxidation in anemic patients. Methods: A number of 30 patients (15 males and 15 females) we...
متن کامل